AGThe Agyekum Group

Independent toxicological evaluation · Exposure-based risk

Scientific governance for beauty, personal care, and ingestible brands.

Exposure-based risk assessment, defensible substantiation, and regulatory alignment across U.S. and EU frameworks. The Agyekum Group (AG) conducts independent toxicological evaluations for cosmetics, personal care, fragrances, ingestibles, and consumer goods — documented for regulatory review, retail compliance, and enforcement-relevant decision-making.

We work with startup, emerging, and enterprise companies across cosmetics, personal care, fragrance, and ingestible categories. Engagements are entered in a selective advisory capacity for brands, platforms, scientific initiatives, and product-safety governance programs.

Engage the practice Services

Platform access available below.

Toxicology intelligence layer

Toxicology Intelligence

Exposure-based safety evaluation, regulatory intelligence, formulation review, and scientific risk assessment — delivered through ToxIntel, the Aᴳ platform for independent consultants, growing brands, manufacturers, retailers, and legal teams.

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Practice capabilities

Where Aᴳ is engaged.

Five practice areas anchor every engagement. Each is signed by a named toxicologist and documented for the next reader — regulator, retailer, or court.

Independent toxicological evaluation

Signed assessments of ingredient and finished-product safety. Hazard characterization, dose–response review, and uncertainty analysis structured for regulator and retailer scrutiny.

Exposure-based risk assessment

Quantitative SED / NOAEL / MoS / BMD analyses per population band. Pathway-specific exposure modelling for dermal, oral, inhalation, and mucosal use.

Cosmetic & consumer product safety

Product-level safety substantiation across cosmetics, personal care, fragrance, ingestibles, and adjacent consumer categories — fit for MoCRA, EU 1223, and IFRA contexts.

Regulatory & litigation support

Toxicology-led regulatory strategy and litigation-aware documentation. Independent expert review, Prop 65 exposure framing, and enforcement-relevant scientific narrative.

Toxicology intelligence via ToxIntel

Aᴳ’s in-house platform — contaminant surveillance, formulation review, compliance passport export, and continuously updated regulatory context. Made available to enterprise clients.

Continuous regulatory monitoring

Federal Register, FDA, CPSC, OEHHA, and FTC signals tracked and interpreted — surfaced below in Toxicology Watch and integrated into client briefings.

Frameworks & methodology

The science we apply.

Every Aᴳ evaluation references the same regulatory frameworks and scientific methodologies a competent authority, retailer, or court would reference. We are explicit about which framework applies, where its boundary lies, and what evidence the engagement produces.

Regulatory frameworks

Modernization of Cosmetics Regulation Act

MoCRA

U.S. cosmetic facility & product registration, adverse-event reporting, safety-substantiation evidence requirements.

Regulation (EC) No 1223/2009

EU Cosmetics Regulation 1223/2009

Cosmetic Product Safety Reports (CPSR), responsible-person obligations, Annex II/III/IV/V/VI ingredient controls.

Safe Drinking Water and Toxic Enforcement Act

California Proposition 65

Exposure-based assessment vs Safe Harbor Levels; warning-decision logic; NSRL / MADL framing.

EU Scientific Committee on Consumer Safety

SCCS Opinions

Authoritative EU opinions on cosmetic ingredients; SCCS Notes of Guidance methodology baseline.

International Fragrance Association

IFRA Standards

Fragrance-ingredient use restrictions, dermal sensitization QRA, category-specific limits.

Scientific frameworks

SED · MoS · BMD methodology

Exposure-based risk assessment

Quantitative dermal, oral, inhalation, and mucosal exposure modelling per population band.

NOAEL / LOAEL → MoS

Margin of Safety

Internal-dose modelling against point-of-departure values; uncertainty factor selection and justification.

Hazard characterization

Ingredient hazard review

Acute, subchronic, and chronic endpoint review across genotoxicity, sensitization, irritation, repro/dev, and systemic toxicity.

WoE evaluation

Weight-of-evidence review

Structured integration of human, animal, in-vitro, and in-silico data streams with study-quality weighting.

Claim & label substantiation

Scientific substantiation

Defensible documentation of safety, performance, and regulatory claims for retailer and litigation contexts.

All assessments are signed by a named toxicologist · documented for regulatory, retailer, and litigation contexts.

01 — Scope

Where the work is documented to support third-party scrutiny.

Regulatory & Governance

Toxicology and risk assessment aligned with EU, FDA, and international frameworks where safety substantiation and exposure analysis are required.

Retail Compliance

Evaluation of formulations and ingredients against exposure-based safety criteria and documentation standards applied in retailer governance.

Legal & Enforcement

Independent toxicological analysis of chemical exposure, dose–response, causation, and complex data — structured to withstand legal scrutiny.

Ingredient & Raw Material

Hazard characterization, exposure considerations, and regulatory status review of ingredients in support of downstream use.

02 — Services

Independent assessment, end to end.

Every engagement is led personally, signed off in writing, and structured for regulatory inspection, retailer review, and enforcement-relevant decision-making.

Macro photograph of a fingertip drawing a swatch of pearlescent cream on skin.

Personal Care & Cosmetics

Independent toxicological evaluation and exposure-based risk assessment for cosmetic and personal care products across all categories.

  • ·Ingredient & formula-level toxicology
  • ·Margin of Safety (MoS) determinations
  • ·U.S. and international framework alignment
  • ·Claims & substantiation support
Macro photograph of amber capsules resting in a cupped palm.

Ingestibles & Supplements

Exposure-based safety evaluation and governance suitable for third-party review across dietary supplements and ingestible wellness products.

  • ·NOAEL / LOAEL / TTC / BMD analysis
  • ·Heavy metals & impurity context
  • ·Pregnancy/breastfeeding population review
  • ·Retailer-ready documentation
Macro photograph of a hand turning the bulb-stopper of a perfume flacon.

Fine Fragrance

Exposure-based risk assessment for fragrance ingredients and finished blends, including sensitization potential and IFRA alignment.

  • ·Ingredient-level hazard & exposure
  • ·IFRA standards & use-level review
  • ·Sensitisation & claim-relevant safety
  • ·Single naturals to complex accords

MoCRA Compliance

Defensible toxicological evaluation supporting MoCRA safety substantiation, adverse-event frameworks, and inspection-ready documentation.

  • ·Safety substantiation dossiers
  • ·Adverse-event reporting frameworks
  • ·GMP-adjacent governance review
  • ·Product listing & labeling context

California Prop 65

Quantitative exposure assessment and regulatory strategy for Proposition 65–listed substances across consumer products.

  • ·Pathway-specific exposure estimates
  • ·NSRL / MADL safe-harbor comparison
  • ·Migration & transfer interpretation
  • ·Enforcement-defensible documentation

PFAS Consultation

Exposure-driven safety assessment for brands navigating PFAS in consumer products and materials, multi-jurisdiction aware.

  • ·Exposure characterization
  • ·Toxicological reference values
  • ·Retailer & state-level restrictions
  • ·Documentation for third-party review

Testing Strategy & Oversight

Toxicology-first study design. Every protocol must reduce uncertainty and align with intended use conditions.

  • ·HRIPT / RIPT / cumulative irritation
  • ·Preservative efficacy testing (PET)
  • ·Benzene / heavy metals / PFAS analytics
  • ·SPF & claim substantiation support
Macro photograph of fingertips brushing pale botanical powder on cream parchment.

Ingredient Safety Review

Hazard characterization and risk-based screening of raw materials and functional components — including scrutinized substances.

  • ·Sensitization & systemic exposure
  • ·Restricted / monitored substance review
  • ·Substitution & reformulation guidance
  • ·Supplier & retailer communication

03 — Philosophy

Testing does not create safety.
Interpretation does.

Testing volume is increasing. The differentiator is not how much testing is performed — it is whether the data meaningfully reduces uncertainty and strengthens governance. Before recommending or reviewing any protocol, we define the decision:

  • · What uncertainty are we resolving?
  • · What claim is being supported?
  • · What exposure assumptions govern the product?
  • · Would additional data materially change the safety conclusion?
“Testing can be outsourced. Interpretation and documentation cannot.”

04 — Practice lead

Every assessment is signed by a named toxicologist.

No anonymous reports, no offshored interpretation. Aᴳ is led personally by Dr. Augustine K. Agyekum, with specialist advisors engaged per assignment.

Portrait of Dr. Augustine K. Agyekum, founder of The Agyekum Group

Founder · Independent Toxicologist

Augustine K. Agyekum, PhD

"Dr. Kwaku"

Founder of Aᴳ, an independent scientific consulting firm specialising in cosmetic and consumer product safety. Dr. Agyekum advises brands, manufacturers, and legal teams on ingredient safety, quantitative risk assessment, and compliance with FDA MoCRA, the EU Cosmetics Regulation, IFRA standards, and California Prop 65 — translating complex toxicological data into clear safety decisions.

Advisory roster

Aᴳ engages specialist advisors on a per-assignment basis — drawing on board-certified toxicologists, regulatory scientists, and analytical chemists when an engagement warrants additional depth. Roster details available on request.

05 — Engage

We take a small number of new engagements each quarter.

Send a short brief — product, jurisdictions, timeline, and the regulatory question that prompted the call. We respond within two business days.

Direct line

regulatory@tagc.us linkedin.com/company/the-agyekum-group

Practice

The Agyekum Group (AG)

Independent toxicology

Engagements

Cosmetics · Personal care

Ingestibles · Fragrance

Jurisdictions

EU · UK · US (FDA / MoCRA)

California Prop 65 · APAC

06 — Toxicology Watch

Consumer product safety intelligence, continuously curated.

Updated 40m ago

Aggregated from the public regulatory record — FDA, CPSC, OEHHA (California Proposition 65), the FTC, and the U.S. Federal Register. Curated to surface the documents that meaningfully shape exposure, claim substantiation, and enforcement posture across cosmetics, personal care, and ingestible categories.

Sources · FDA Cosmetics · CPSC · Proposition 65 · Consumer Protection · Cosmetics · Toxic Substances · Hazardous Materials · Environmental Protection

Ecosystem architecture

Authority

AG Consulting

Independent scientific governance, toxicological evaluation, and regulatory interpretation — signed by a named toxicologist.

tagc.us

Enterprise infrastructure

ToxIntel Platform

Enterprise toxicology intelligence infrastructure — exposure assessment, contaminant surveillance, and compliance documentation for brands and retailers.

toxintel.tagc.us

Consumer distribution

GlowCheck Consumer App

Consumer-facing distribution layer of the broader Aᴳ ecosystem. Operated and positioned separately from enterprise infrastructure.

getglowcheck.app